Synoviocyte Innate Immune Responses: II. Pivotal Role of IFN Regulatory Factor 3

Pivotal Role of IFN Regulatory Factor 3 Synoviocyte Innate Immune

Pivotal Role of IFN Regulatory Factor 3 Synoviocyte Innate Immune Responses : II

Differential Regulation of Interferon Synoviocyte Innate Immune Responses: I

Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis.

OBJECTIVES Innate immune responses in the rheumatoid synovium contribute to inflammation and joint destruction in RA. Two IκB kinase (IKK)-related kinases, TNF receptor associated factor (TRAF) family member-associated nuclear factor κ-light-chain enhancer of activated B cells (NF-κB) activator (TANK)-binding kinase 1 (TBK1) and IKKε, potentially regulate synovitis by activating IFN response ge...

Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4.

IFN-regulatory factor (IRF)-4 is a member of the IRF family of transcription factors expressed in lymphocytes and macrophages. The previous studies using mice deficient in the IRF-4 gene showed profound defects in function of both B and T cells. To further investigate the role of IRF-4 in CD4(+) T cell function, IRF-4(-/-) mice were challenged with the intracellular pathogen Leishmania major. T...